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pentobarbital will lower the extent or impact of clozapine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will lower the level or outcome of oliceridine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. If coadministration that has a CYP3A4 inducer is important, consider